0.5% extract in diabetes mellitus type 2 mice. The animals were divided into 4 groups: group Ⅰ (normal) rats were
fed standard diet (12% of calories as fat); group Ⅱ (control) rats were fed HFD (45% of calories as fat) for 2 weeks
and then injected with STZ (45 mg/kg); group Ⅲ (treatment 1) and Ⅳ (treatment 2) rats were fed a diet containing
0.1% and 0.5% Angelica gigas Nakai leaf extracts for 4 weeks after type 2 diabetes mellitus induction. The diabetic
clinical markers, body weight and food intake, organ weight, blood glucose level, serum glucose level, total
cholesterol level, HDL-cholesterol level, LDL-cholesterol level, triglyceride level, glycogen level in liver were
measured. Blood glucose level of the A. gigas Nakai leaf 0.1% and 0.5% extract groups were lower than control
group. Serum glucose level of the A. gigas Nakai leaf 0.1% and 0.5% extract groups were lower than control group.
Organ weight of the A. gigas Nakai leaf 0.1% and 0.5% extract groups were not shown the significant difference
between control group. Total cholesterol level, HDL-cholesterol level, LDL-cholesterol level, triglyceride level of the
A. gigas Nakai leaf 0.1% and 0.5% extract groups were not shown the significant difference between control group.
Glycogen contents in liver significantly higher then control group, and has not significantly difference between
normal group. We suggest that A. gigas Nakai leaf extract may have the control effects of diabetes mellitus by
improving blood glucose and additional anti-diabetic experiments required.
2-김희연STZ(최종).pdf
