Article Info 제29권 3호 강원 농업생명환경연구 Vol.29, No.3, pp.153-171, 2017
Title Role of Antihypertensive Peptides from Plant (sesame, almond and pumpkin) Seed Storage Protein
Author Chelliah, R.1 , S. R. Ramakrishnan2 and D. H. Oh1*
Institutions 1Department of Food Science and Biotechnology, College of Agriculture and Life Science, Kangwon National University, Chuncheon 24341, Korea
2School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea 
Abstract Proteins are a potential source of health-promoting biomolecules with medical, nutraceutical,
and/or food applications. In particular, plant proteins, including globular proteins, represent
important functional ingredients in many processed food products. Thus, the current study
investigated and compared the antihypertensive properties of globulin, amandin, and cucurbitin proteins isolated from white sesame, almond, and pumpkin seeds, respectively. Extracted globulin, amandin, and cucurbitin proteins were shown to each comprise acidic and basic polypeptides of varying sizes (globulin polypeptides, 30－33 and 20－24 kDa, respectively; amandin polypeptides, 40－42 and 15－20 kDa, respectively; cucurbitin polypeptides, 35－42 and 20－25 kDa, respectively). The alpha amylase-inhibiting activity and resulting antihypertensive effects exhibited by the isolated 11S globulin, amandin, and cucurbitin polypeptides were characterized. Finally, the current study also reviewed current literature with regard to the properties of various peptides released by plant proteases, and their mitigating effects on disorders such as hypertension, diabetes, obesity, and cancer.
Keyword Alpha amylase, Amandin, Antihypertensive, Cucurbitin, Globular proteins
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