| Article Info |
제29권 3호 강원 농업생명환경연구 Vol.29, No.3, pp.185-192, 2017
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| Title |
Antioxidant and Anti-aging Effects of Extracts from Rhododendron mucronulatum Turcz. in Human Dermal Fibroblast
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| Author |
Choi, S. I.1 , S. Lee2 , H. J. Lee2 , B. J. Kim2 , J. Yeo2 , T. D. Jung1 , B. Y. Cho1 , S. H. Choi1 , X. Han1 , W. S. Sim1 , J. H. Lee1 , O. H. Lee1 and J. S. Lee2*
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| Institutions |
1Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea
2Biological and Genetic Resources Assessment Division, National Institute of Biological Resources, Incheon 22689, Korea
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| Abstract |
Skin aging is associated with increased reactive oxygen species (ROS) production by human cells, which is characterized by wrinkles and atypical pigmentation. Use of antioxidants is an effective approach to prevent symptoms associated with ROS-induced skin aging. Although synthetic antioxidants have been used to remove free radicals, several studies have reported that the synthetic antioxidants have side effects that cause long-term edema, which subsequently results in cancer and intracellular toxicity. Therefore, the study of safe and functional antioxidants derived
from natural products is necessary for replacement of synthetic antioxidants. In this study, the antioxidant and anti-aging effect of Rhododendron mucronulatum Turcz. extracts (RTE) on human dermal fibroblasts (HDFs) were investigated. We confirmed that RTE markedly reduced hydrogen peroxide-induced cell damage, intracellular ROS, and oxidative stress-induced senescence in HDFs. These results suggest that RTE is potential natural source of antioxidant and anti-aging compounds.
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| Keyword |
Anti-aging, Antioxidant, Human dermal fibroblast, Reactive oxygen species
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 04_(185-192)J4_201700026 이종석.pdf
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